Anti Synthetase Syndrome: An Underrecognized Autoimmune Disease with Multisystem Involvement
Mrs. Sneha Smriti Guha
Medical Surgical Nursing Dept. P.G.College of Nuirsing, Bhilai, (CG)
Anti synthetase Syndrome (ASSD) represents a unique subset of idiopathic inflammatory myopathies characterized by specific autoantibodies targeting aminoacyl-tRNA synthetase enzymes. Since its first description in the late twentieth century, ASSD has emerged as a clinically significant autoimmune condition due to its potentially severe pulmonary and muscular complications.
The disease predominantly affects adults and exhibits a higher prevalence among women. Because symptoms often develop gradually and vary considerably among patients, diagnosis is frequently delayed. Increased awareness among healthcare professionals is essential to ensure timely recognition and treatment.
DOI: · Licence: All rights reserved
Article
References
1. Betteridge ZE, McHugh NJ. Myositis-specific autoantibodies: An important tool to support diagnosis of myositis. Journal of Internal Medicine.2. Connors GR, Christopher-Stine L, Oddis CV, Danoff SK. Interstitial lung disease associated with anti-synthetase syndrome.
3. Witt LJ, Curran JJ, Strek ME. The diagnosis and treatment of anti-synthetase syndrome.
4. Solomon J, Swigris JJ, Brown KK. Myositis-related interstitial lung disease and anti-synthetase syndrome.
5. Aggarwal R, Cassidy E, Fertig N, et al. Patients with non-Jo-1 anti-synthetase antibodies.